SPEED: (S)ignaling (P)athway (E)nrichment using (E)xperimental (D)atasets

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The SPEED enrichment algorithm extracts signature gene sets per pathway from microarray experiments and compares an input gene list against the signature genes using Fisher's exact test. The reported p-value is a one-tailed calculation. Multiple hypothesis correction is achieved by calculating a false discovery rate described in Blüthgen et al, Nucleic Acids Res., 2005.

Please enter your gene list below (limited to 1000 IDs):

Click buttons for sample lists:

Pathways to include:
  • TGFB
  • TLR
  • H2O2
  • MAPK_only
  • IL-1
  • VEGF
  • PI3K_only
  • Wnt
  • TNFa
Max. absolute z-score percentile: %
Min. percent overlap across experiments: %
Max. expression level percentile: %
Signature genes must be unique:

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Incl. Background List: