SPEED: (S)ignaling (P)athway (E)nrichment using (E)xperimental (D)atasets

 Home   Run SPEED   Download Annotations   Database Statistics   Suggest Pathways   Help 

The SPEED database stores z-score normalized microarray data from perturbation experiments for specific signaling pathways. All microarray data is downloaded from the Gene Expression Omnibus (GEO) at NCBI. The GEO series for the perturbation experiments are noted per pathway.


Number of Genes: 21485
Number of Measurements: 5896213
TLR Experiments: 39
GSE3720, GSE1541, GSE15219, GSE510316, GSE2706, GSE7850, GSE53982, GSE16650, GSE518047, GSE3491, GSE5504, GSE4748, GSE15038, GSE8608, GSE9988, GSE5883
TGFB Experiments: 38
GSE10847, GSE1724, GSE14491, GSE13837, GSE1805, GSE1802, GSE8730, GSE5457
H2O2 Experiments: 2
GSE5339
MAPK_only Experiments: 4
GSE6521, GSE3542, GSE14934
IL-1 Experiments: 6
GSE9120, GSE973, GSE8515
MAPK_PI3K Experiments: 39
GSE6521, GSE6783, GSE13009, GSE11729, GSE8471, GSE6784, GSE3542, GSE7403, GSE14934, GSE6462, GSE14256, GSE10778
VEGF Experiments: 25
GSE18913, GSE11228, GSE3891, GSE18195, GSE837, GSE17777, GSE15464, GSE10778
PI3K_only Experiments: 11
GSE3737, GSE6521, GSE7403, GSE14934, GSE7562
Wnt Experiments: 6
GSE11916, GSE1473, GSE14107, GSE16186, GSE17385
JAK-STAT Experiments: 14
GSE1925, GSE8059, GSE8687, GSE19082, GSE440, GSE10685, GSE1432, GSE3183
TNFa Experiments: 31
GSE1474, GSE9055, GSE11467, GSE13837, GSE516, GSE2624, GSE8166, GSE2489




IL-1 Data Details

GSE8515
Cell Line:Human monocyte-derived macrophages
Modification:with IL-1 (15 ng/ml)
Time:4 h
Control Samples: GSM211500, GSM211501, GSM211502, GSM211503, GSM211504
Experimental Samples: GSM211505, GSM211506, GSM211507, GSM211508, GSM211509

GSE9120a
Cell Line:Cultured epidermal keratinocytes
Modification:treated with 25 ng/ml human recombinant IL-1
Time:1 h
Control Samples: GSM230880
Experimental Samples: GSM230879

GSE9120b
Cell Line:Cultured epidermal keratinocytes
Modification:treated with 25 ng/ml human recombinant IL-1
Time:4 h
Control Samples: GSM230881
Experimental Samples: GSM230882

GSE973a
Cell Line:HUVEC
Modification:treated with 100 U/ml human IL-1
Time:0.5 h
Control Samples: GSM15389
Experimental Samples: GSM15390

GSE973b
Cell Line:HUVEC
Modification:treated with 100 U/ml human IL-1
Time:1 h
Control Samples: GSM15389
Experimental Samples: GSM15391

GSE973c
Cell Line:HUVEC
Modification:treated with 100 U/ml human IL-1
Time:2.5 h
Control Samples: GSM15389
Experimental Samples: GSM15392